Molecules | |
Anthraquinones of the Roots of Pentas micrantha | |
Milkyas Endale1  Annabel Ekberg1  John Patrick Alao1  Hoseah M. Akala1  Albert Ndakala1  Per Sunnerhagen1  Máté Erdélyi1  | |
[1] 1Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya | |
关键词: anthraquinone; malaria; Pentas micrantha; Rubiaceae; 5; 6-dihydroxylucidin-11-O-methyl ether; | |
DOI : 10.3390/molecules18010311 | |
来源: mdpi | |
【 摘 要 】
Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 μg/mL) and D6-strains (4.00 μg/mL) of Plasmodium falciparum and low cytotoxicity (>450 μg/mL, MCF-7 cell line). Chromatographic separation of the extract yielded nine anthraquinones, of which 5,6-dihydroxylucidin-11-O-methyl ether is new. Isolation of a munjistin derivative from the genus Pentas is reported here for the first time. The isolated constituents were identified by NMR and mass spectrometric techniques and showed low antiplasmodial activities.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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