Anthraquinones of the Roots of Pentas micrantha

Molecules

Milkyas Endale¹  Annabel Ekberg¹  John Patrick Alao¹  Hoseah M. Akala¹  Albert Ndakala¹  Per Sunnerhagen¹  Máté Erdélyi¹ 

[1] ¹Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya

关键词: anthraquinone;    malaria;    Pentas micrantha;    Rubiaceae;    5;    6-dihydroxylucidin-11-O-methyl ether;   

DOI  :  10.3390/molecules18010311

来源: mdpi

【 摘 要 】

Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 μg/mL) and D6-strains (4.00 μg/mL) of Plasmodium falciparum and low cytotoxicity (>450 μg/mL, MCF-7 cell line). Chromatographic separation of the extract yielded nine anthraquinones, of which 5,6-dihydroxylucidin-11-O-methyl ether is new. Isolation of a munjistin derivative from the genus Pentas is reported here for the first time. The isolated constituents were identified by NMR and mass spectrometric techniques and showed low antiplasmodial activities.

【 授权许可】

CC BY   
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