Nutrients | |
Does Vitamin C Deficiency Promote Fatty Liver Disease Development? | |
David Højland Ipsen1  Pernille Tveden-Nyborg1  | |
[1] Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, Frederiksberg C, 1870 Copenhagen, Denmark; | |
关键词: antioxidants; obesity; oxidative stress; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; reactive oxygen species; vitamin C; vitamin C deficiency; | |
DOI : 10.3390/nu6125473 | |
来源: mdpi | |
【 摘 要 】
Obesity and the subsequent reprogramming of the white adipose tissue are linked to human disease-complexes including metabolic syndrome and concurrent non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The dietary imposed dyslipidemia promotes redox imbalance by the generation of excess levels of reactive oxygen species and induces adipocyte dysfunction and reprogramming, leading to a low grade systemic inflammation and ectopic lipid deposition, e.g., in the liver, hereby promoting a vicious circle in which dietary factors initiate a metabolic change that further exacerbates the negative consequences of an adverse life-style. Large epidemiological studies and findings from controlled
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190018966ZK.pdf | 592KB | download |