International Journal of Molecular Sciences | |
Lidocaine Sensitizes the Cytotoxicity of Cisplatin in Breast Cancer Cells via Up-Regulation of |
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Kehan Li2  Jianxue Yang1  Xuechang Han2  | |
[1] Department of Neurology, the First Affiliated Hospital of Henan Science and Technology University, Luoyang 471003, China; E-Mail:;Department of Anesthesiology, the First Affiliated Hospital of Henan Science and Technology University, Luoyang 471003, China; E-Mail: | |
关键词: lidocaine; DNA demethylation; cisplatin; breast cancer cells; apoptosis; | |
DOI : 10.3390/ijms151223519 | |
来源: mdpi | |
【 摘 要 】
It has been reported that lidocaine is toxic to various types of cells. And a recent study has confirmed that lidocaine exerts a demethylation effect and regulates the proliferation of human breast cancer cell lines. To recognize a potential anti-tumor effect of lidocaine, we evaluated the DNA demethylation by lidocaine in human breast cancer lines, MCF-7 and MDA-MB-231 cells, and determined the influence of demethylation on the toxicity to these cells of cisplatin, which is a commonly utilized anti-tumor agent for breast cancer. Results demonstrated that lidocaine promoted a significant global genomic demethylation, and particularly in the promoters of tumor suppressive genes (TSGs),
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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