期刊论文详细信息
Nutrients
The Relationship between Serum 25-Hydroxyvitamin D Concentration, Cardiorespiratory Fitness, and Insulin Resistance in Japanese Men
Xiaomin Sun2  Zhen-Bo Cao1  Kumpei Tanisawa2  Tomoko Ito2  Satomi Oshima3 
[1] School of Kinesiology, Shanghai University of Sport, 399 Chang Hai Road, Shanghai 200438, China;Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan; E-Mails:;Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan; E-Mails:
关键词: vitamin D;    cardiorespiratory fitness;    insulin resistance;    visceral fat;   
DOI  :  10.3390/nu7010091
来源: mdpi
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【 摘 要 】

Here, we aim to investigate the independent and combined associations of serum 25-hydroxyvitamin D (25(OH)D) and cardiorespiratory fitness (CRF) with glucose metabolism. Fasting blood samples of 107 men aged 40–79 years were analyzed for 25(OH)D, glucose, insulin, glycated hemoglobin, and lipid profile. Homeostasis model assessment of insulin resistance index (HOMA-IR) was calculated from the fasting concentrations of glucose and insulin. Visceral fat area (VFA) was determined by magnetic resonance imaging and CRF by measuring maximal oxygen uptake. Median 25(OH)D concentration was 36.3 nmol/L, while the prevalence of 25(OH)D deficiency was 74.8%. Participants with high CRF had significantly lower HOMA-IR, glycated hemoglobin, and insulin values than participants with low CRF (p < 0.05). Higher 25(OH)D concentration was strongly correlated with lower HOMA-IR and insulin values independent of VFA (p < 0.01) but significantly affected by CRF. In the high CRF group, participants with higher 25(OH)D concentration had lower HOMA-IR values than participants with low 25(OH)D concentration (p < 0.05). Higher 25(OH)D and CRF are crucial for reducing insulin resistance regardless of abdominal fat. In addition, higher 25(OH)D concentration may strengthen the effect of CRF on reducing insulin resistance in middle-aged and elderly Japanese men with high CRF.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

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