The Relationship between Serum 25-Hydroxyvitamin D Concentration, Cardiorespiratory Fitness, and Insulin Resistance in Japanese Men

卷:7

Sun, Xiaomin ; Cao, Zhen-Bo ; Tanisawa, Kumpei ; Ito, Tomoko ; Oshima, Satomi ; Higuchi, Mitsuru

Shanghai Univ Sport

关键词: vitamin D;    cardiorespiratory fitness;    insulin resistance;    visceral fat;   

DOI  :  10.3390/nu7010091

学科分类：食品科学和技术

【 摘 要 】

Here, we aim to investigate the independent and combined associations of serum 25-hydroxyvitamin D (25(OH)D) and cardiorespiratory fitness (CRF) with glucose metabolism. Fasting blood samples of 107 men aged 40-79 years were analyzed for 25(OH) D, glucose, insulin, glycated hemoglobin, and lipid profile. Homeostasis model assessment of insulin resistance index (HOMA-IR) was calculated from the fasting concentrations of glucose and insulin. Visceral fat area (VFA) was determined by magnetic resonance imaging and CRF by measuring maximal oxygen uptake. Median 25(OH) D concentration was 36.3 nmol/L, while the prevalence of 25(OH)D deficiency was 74.8%. Participants with high CRF had significantly lower HOMA-IR, glycated hemoglobin, and insulin values than participants with low CRF (p < 0.05). Higher 25(OH) D concentration was strongly correlated with lower HOMA-IR and insulin values independent of VFA (p < 0.01) but significantly affected by CRF. In the high CRF group, participants with higher 25(OH) D concentration had lower HOMA-IR values than participants with low 25(OH) D concentration (p < 0.05). Higher 25(OH) D and CRF are crucial for reducing insulin resistance regardless of abdominal fat. In addition, higher 25(OH) D concentration may strengthen the effect of CRF on reducing insulin resistance in middle-aged and elderly Japanese men with high CRF.