New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla

Molecules

Lei Hou²  Gang Ding²  Baolin Guo²  Wenhua Huang²  Xiaojian Zhang¹  Zhiyong Sun¹  Xiangfen Shi¹ 

[1] The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; E-Mails:;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China; E-Mails:

关键词: Alpinia oxyphylla;    sesquiterpenoids;    diterpenoid;   

DOI  :  10.3390/molecules20011551

来源: mdpi

【 摘 要 】

The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla, together with six known compounds 7–12. The inhibitory effects of compounds 1–12 on α-glucosidase were evaluated, and compounds 1, 3 and 6 showed moderate bioactive effect, with inhibitory rates of 10.3%, 10.0% and 11.5%, respectively, compared to the positive control acarbose (41.9%) at 20 µg/mL.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.