Molecules | |
Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii | |
Yu-Chang Chen1  Yen-Cheng Li1  Bang-Jau You1  Wen-Te Chang1  Louis Kuoping Chao1  Lee-Chiang Lo1  Sheng-Yang Wang1  Guan-Jhong Huang1  | |
[1] 1Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources,College of Pharmacy, China Medical University, Taichung 404, Taiwan | |
关键词: Cunninghamia konishii; Taxodiaceae; diterpenoid; 7; 20-dinorabietane; konishone; 3b-hydroxy-5; 6-dehydrosugiol; anti-inflammatory; | |
DOI : 10.3390/molecules18010682 | |
来源: mdpi | |
【 摘 要 】
Two new diterpenoids, konishone (1) and 3b-hydroxy-5,6-dehydrosugiol (2), along with three known diterpenoids—hinokiol (3), sugiol (4), and 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (5)—were isolated from the wood of Cunninghamia konishii. Compound 1 is a novel skeleton of the 7,20-dinorabietane-type diterpene. In addition, when RAW264.7 macrophages were treated with different concentrations of compounds 1, 3, and 5 together with LPS, a significant concentration-dependent inhibition of NO production was detected. The IC50 values for inhibition of nitrite production of compounds 1, 3, and 5 were about 9.8 ± 0.7, 7.9 ± 0.9, and 9.3 ± 1.3 μg/mL, respectively. This study presents the potential utilization of compounds 1, 3, and 5, as lead compounds for the development of anti-inflammatory drugs.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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