Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii

Molecules

Yu-Chang Chen¹  Yen-Cheng Li¹  Bang-Jau You¹  Wen-Te Chang¹  Louis Kuoping Chao¹  Lee-Chiang Lo¹  Sheng-Yang Wang¹  Guan-Jhong Huang¹ 

[1] ¹Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources,College of Pharmacy, China Medical University, Taichung 404, Taiwan

关键词: Cunninghamia konishii;    Taxodiaceae;    diterpenoid;    7;    20-dinorabietane;    konishone;    3b-hydroxy-5;    6-dehydrosugiol;    anti-inflammatory;   

DOI  :  10.3390/molecules18010682

来源: mdpi

【 摘 要 】

Two new diterpenoids, konishone (1) and 3b-hydroxy-5,6-dehydrosugiol (2), along with three known diterpenoids—hinokiol (3), sugiol (4), and 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (5)—were isolated from the wood of Cunninghamia konishii. Compound 1 is a novel skeleton of the 7,20-dinorabietane-type diterpene. In addition, when RAW264.7 macrophages were treated with different concentrations of compounds 1, 3, and 5 together with LPS, a significant concentration-dependent inhibition of NO production was detected. The IC₅₀ values for inhibition of nitrite production of compounds 1, 3, and 5 were about 9.8 ± 0.7, 7.9 ± 0.9, and 9.3 ± 1.3 μg/mL, respectively. This study presents the potential utilization of compounds 1, 3, and 5, as lead compounds for the development of anti-inflammatory drugs.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.