DNA under Force: Mechanics, Electrostatics, and Hydration

Nanomaterials

Jingqiang Li¹  Sithara S. Wijeratne¹  Xiangyun Qiu²  Ching-Hwa Kiang¹ 

[1] Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA; E-Mails:;Department of Physics, George Washington University, Washington, DC 20052, USA

关键词: DNA;    mechanics;    electrostatics;    hydration;   

DOI  :  10.3390/nano5010246

来源: mdpi

【 摘 要 】

Quantifying the basic intra- and inter-molecular forces of DNA has helped us to better understand and further predict the behavior of DNA. Single molecule technique elucidates the mechanics of DNA under applied external forces, sometimes under extreme forces. On the other hand, ensemble studies of DNA molecular force allow us to extend our understanding of DNA molecules under other forces such as electrostatic and hydration forces. Using a variety of techniques, we can have a comprehensive understanding of DNA molecular forces, which is crucial in unraveling the complex DNA functions in living cells as well as in designing a system that utilizes the unique properties of DNA in nanotechnology.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.