Recent Advances in Proteomic Studies of Adipose Tissues and Adipocytes

International Journal of Molecular Sciences

Eun Young Kim¹  Won Kon Kim¹  Kyoung-Jin Oh¹  Baek Soo Han¹  Sang Chul Lee¹  Kwang-Hee Bae¹ 

[1] Functional Genomics Research Center, KRIBB, Daejeon 305-806, Korea; E-Mails:

关键词: adipocytes;    adipogenesis;    adipose tissue;    browning;    proteomics;   

DOI  :  10.3390/ijms16034581

来源: mdpi

【 摘 要 】

Obesity is a chronic disease that is associated with significantly increased levels of risk of a number of metabolic disorders. Despite these enhanced health risks, the worldwide prevalence of obesity has increased dramatically over the past few decades. Obesity is caused by the accumulation of an abnormal amount of body fat in adipose tissue, which is composed mostly of adipocytes. Thus, a deeper understanding of the regulation mechanism of adipose tissue and/or adipocytes can provide a clue for overcoming obesity-related metabolic diseases. In this review, we describe recent advances in the study of adipose tissue and/or adipocytes, focusing on proteomic approaches. In addition, we suggest future research directions for proteomic studies which may lead to novel treatments of obesity and obesity-related diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.