Lipophilic Micronutrients and Adipose Tissue Biology

Nutrients

Jean-François Landrier¹  Julie Marcotorchino¹ 

[1] Institut National de Recherche Agronomique (INRA), UMR 1260, F-13385, Marseille, France;

关键词: adipose tissue;    adipocytes;    vitamins;    micronutrients;    obesity;    insulin resistance;    inflammation;    metabolism;    adipogenesis;   

DOI  :  10.3390/nu4111622

来源: mdpi

【 摘 要 】

Lipophilic micronutrients (LM) constitute a large family of molecules including several vitamins (A, D, E, K) and carotenoids. Their ability to regulate gene expression is becoming increasingly clear and constitutes an important part of nutrigenomics. Interestingly, adipose tissue is not only a main storage site for these molecules within the body, but it is also subjected to the regulatory effects of LM. Indeed, several gene regulations have been described in adipose tissue that could strongly impact its biology with respect to the modulation of adipogenesis, inflammatory status, or energy homeostasis and metabolism, among others. The repercussions in terms of health effects of such regulations in the context of obesity and associated pathologies represent an exciting and emerging field of research. The present review will focus on the regulatory effects of vitamin A, D, E and K as well as carotenoids on adipose tissue biology and physiology, notably in the context of obesity and associated disorders.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.