Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus

Marine Drugs

Xuekui Xia³  Jun Qi³  Yayue Liu¹  Airong Jia³  Yonggang Zhang³  Changheng Liu³  Cuiling Gao²  Zhigang She¹ 

[1] School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China; E-Mail:;Shandong Provincial Key Laboratory of Test Technology for Material Chemical Safety, Jinan 250014, China;Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, China; E-Mails:

关键词: Epicoccum sp.;    secondary metabolites;    isopimarane diterpene;    X-ray diffraction;    α-glucosidase inhibitory activity;   

DOI  :  10.3390/md13031124

来源: mdpi

【 摘 要 】

One new isopimarane diterpene (1), together with two known compounds, 11-deoxydiaporthein A (2) and iso-pimara-8(14),15-diene (3) were isolated from the culture of Epicoccum sp., which was associated with Apostichopus japonicus. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data. The absolute configuration of Compound 1 was deduced by a single-crystal X-ray diffraction experiment using CuKα radiation. In the bioactivity assay, both Compounds 1 and 2 exhibited α-glucosidase inhibitory activity with IC₅₀ values of 4.6 ± 0.1 and 11.9 ± 0.4 μM, respectively. This was the first report on isopimarane diterpenes with α-glucosidase inhibitory activity.

【 授权许可】

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