The Anthraquinone Derivatives from the Fungus Alternaria sp. XZSBG-1 from the Saline Lake in Bange, Tibet, China

Molecules

Bin Chen¹  Qiong Shen¹  Xun Zhu²  Yongcheng Lin¹ 

[1] School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China; E-Mail:;Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275, China; E-Mail:

关键词: Alternaria;    secondary metabolites;    anthraquinones;    alterporriols;    altersolanols;    cytotoxicity;    enzyme inhibitory activity;   

DOI  :  10.3390/molecules191016529

来源: mdpi

【 摘 要 】

Four new anthraquinone derivatives 1–4 were obtained along with seven known compounds 5–11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC₅₀ value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC₅₀ values of 3.03 and 8.09 μM, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.