International Journal of Molecular Sciences | |
Visfatin Mediates SCLC Cells Migration across Brain Endothelial Cells through Upregulation of CCL2 | |
Tingting Liu2  Ziwei Miao2  Jiusheng Jiang2  Shuai Yuan2  Wengang Fang2  Bo Li2  Yuhua Chen1  | |
[1] Key Lab of Cell Biology, Ministry of Public Health, Key Lab of Medical Cell Biology, Ministry of Education, Department of Developmental Biology, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China; | |
关键词: brain metastasis; SCLC; visfatin; transendothelial migration; blood–brain barrier (BBB); CC chemokine ligand 2 (CCL2); | |
DOI : 10.3390/ijms160511439 | |
来源: mdpi | |
【 摘 要 】
Small-cell lung cancer (SCLC) is characterized as an aggressive tumor with brain metastasis. Although preventing SCLC metastasis to the brain is immensely important for survival, the molecular mechanisms of SCLC cells penetrating the blood–brain barrier (BBB) are largely unknown. Recently, visfatin has been considered as a novel pro-inflammatory adipocytokine involved in various cancers. Herein, we present evidence that elevated levels of visfatin in the serum of SCLC patients were associated with brain metastasis, and visfain was increased in NCI-H446 cells, a SCLC cell line, during interacting with human brain microvascular endothelial cells (HBMEC). Using
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190012514ZK.pdf | 4169KB | download |