| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| FMNL1 promotes proliferation and migration of leukemia cells | |
| 关键词: formins; leukemogenesis; cell motility; transendothelial migration; Rac1; | |
| DOI : 10.1189/jlb.0113057 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
 PDF
|
|
【 摘 要 】
ThehumanFMNL1isexpressedpredominantlyinhematopoieticcellsandhasbeendescribedpreviouslyasoverexpressedinhematopoieticmalignancies.However,itisnotknownwhetherFMNL1contributestoleukemogenesis.Here,weinvestigatetheFMNL1functionusingtwodifferenthumanleukemiamodels:NamalwaandK562celllines.FMNL1depletionreducedcellproliferationandcolonyformationinbothleukemiccelltypes,aswellasadecreaseinthetumorgrowthofFMNL1‐depletedNamalwacellxenografts.Inaddition,therewasadecreaseinmigrationandinTEMinFMNL1‐depletedNamalwacells.FMNL1endogenouslyassociateswithRac1,andFMNL1silencingresultedinanincreasedRac1activity.ThereducedmigrationobservedinFMNL1‐depletedcellswasrestoredbyinhibitingRacactivity.OurresultsindicatethatFMNL1stimulatesleukemiacellproliferationaswellasmigration.ThissuggeststhatFMNL1contributestoleukemogenesisandcouldactinpartthroughRac1regulation...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043144099ZK.pdf | 3577KB |  download |
878987797
028-85220240
