Silver Nanoparticles as Potential Antibacterial Agents

Molecules

Gianluigi Franci¹  Annarita Falanga⁴  Stefania Galdiero⁴  Luciana Palomba²  Mahendra Rai³  Giancarlo Morelli⁴  Massimiliano Galdiero⁵ 

[1] Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy; E-Mail:;Department of Experimental Medicine, II University of Naples, 80138 Naples, Italy; E-Mail:;Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra 444602, India; E-Mail:;Department of Pharmacy, University of Naples Federico II, 80100 Naples, Italy; E-Mails:;CIRPEB, and DFM, University of Naples Federico II, 80100 Naples, Italy

关键词: AgNPs;    antibacterial;    resistence;    biofilm;   

DOI  :  10.3390/molecules20058856

来源: mdpi

【 摘 要 】

Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advances in nanotechnology have opened new horizons in nanomedicine, allowing the synthesis of nanoparticles that can be assembled into complex architectures. Novel studies and technologies are devoted to understanding the mechanisms of disease for the design of new drugs, but unfortunately infectious diseases continue to be a major health burden worldwide. Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. Currently nanotechnology and nanomaterials are fully integrated in common applications and objects that we use every day. In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. This review aims to summarize the emerging efforts to address current challenges and solutions in the treatment of infectious diseases, particularly the use of nanosilver antimicrobials.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.