Biological Properties of Fucoxanthin in Oil Recovered from Two Brown Seaweeds Using Supercritical CO2 Extraction

Marine Drugs

Saravana Periaswamy Sivagnanam¹  Shipeng Yin¹  Jae Hyung Choi²  Yong Beom Park²  Hee Chul Woo²  Byung Soo Chun¹ 

[1] Department of Food Science and Technology, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 608-737, Korea; E-Mails:;Department of Chemical Engineering, Pukyong National University, 365 Sinseon-ro, 599-1 Daeyeon-3dong, Nam-gu, Busan 608-737, Korea; E-Mails:

关键词: brown seaweed;    Sargassum horneri;    Saccharina japonica;    supercritical CO₂ fucoxanthin;    fatty acid;    antioxidant;    antimicrobial;    antihypertensive;   

DOI  :  10.3390/md13063422

来源: mdpi

【 摘 要 】

The bioactive materials in brown seaweeds hold great interest for developing new drugs and healthy foods. The oil content in brown seaweeds (Saccharina japonica and Sargassum horneri) was extracted by using environmentally friendly supercritical CO₂ (SC-CO₂) with ethanol as a co-solvent in a semi-batch flow extraction process and compared the results with a conventional extraction process using hexane, ethanol, and acetone mixed with methanol (1:1, v/v). The SC-CO₂ method was used at a temperature of 45 °C and pressure of 250 bar. The flow rate of CO₂ (27 g/min) was constant for the entire extraction period of 2 h. The obtained oil from the brown seaweeds was analyzed to determine their valuable compounds such as fatty acids, phenolic compounds, fucoxanthin and biological properties including antioxidant, antimicrobial, and antihypertension effects. The amounts of fucoxanthin extracted from the SC-CO₂ oils of S. japonica and S. horneri were 0.41 ± 0.05 and 0.77 ± 0.07 mg/g, respectively. High antihypertensive activity was detected when using mixed acetone and methanol, whereas the phenolic content and antioxidant property were higher in the oil extracted by SC-CO₂. The acetone–methanol mix extracts exhibited better antimicrobial activities than those obtained by other means. Thus, the SC-CO₂ extraction process appears to be a good method for obtaining valuable compounds from both brown seaweeds, and showed stronger biological activity than that obtained by the conventional extraction process.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.