Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

Marine Drugs

Ivan Rui Lopes Albuquerque²  Sara Lima Cordeiro²  Dayanne Lopes Gomes²  Juliana Luporini Dreyfuss¹  Luciana Guimar฾s Alves Filgueira²  Edda Lisboa Leite²  Helena Bonciani Nader¹ 

[1] Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo-SP 04044-020, Brazil; E-Mails:;Laboratory of Biotechnology of Natural Polymers (BIOPOL), Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), Natal-RN 59078-970, Brazil; E-Mails:

关键词: fucan;    brown seaweed;    pain;    analgesic;    dictyotales;   

DOI  :  10.3390/md11082722

来源: mdpi

【 摘 要 】

Fucan is a term that defines a family of homo- and hetero-polysaccharides containing sulfated l-fucose in its structure. In this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-α). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. In summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.