In Vivo Nanodetoxication for Acute Uranium Exposure

Molecules

Luis Guzmán²  Esteban F. Durán-Lara²  Wendy Donoso²  Fabiane M. Nachtigall¹  Leonardo S. Santos² 

[1] Nanobiotechnology Division at Talca University, Fraunhofer Chile Research Foundation-Center for Systems Biotechnology, FCR-CSB, P.O. Box 747, Talca 3460000, Maule, Chile; E-Mail:;Laboratory of Asymmetric Synthesis, Institute of Chemistry and Natural Resources, University of Talca, P.O. Box 747, Talca 3460000, Maule, Chile; E-Mails:

关键词: chelating agent;    uranium;    PAMAM dendrimer derivatives;    acute intoxication;   

DOI  :  10.3390/molecules200611017

来源: mdpi

【 摘 要 】

Accidental exposure to uranium is a matter of concern, as U(VI) is nephrotoxic in both human and animal models, and its toxicity is associated to chemical toxicity instead of radioactivity. We synthesized different PAMAM G4 and G5 derivatives in order to prove their interaction with uranium and their effect on the viability of red blood cells in vitro. Furthermore, we prove the effectiveness of the selected dendrimers in an animal model of acute uranium intoxication. The dendrimer PAMAM G4-Lys-Fmoc-Cbz demonstrated the ability to chelate the uranyl ion in vivo, improving the biochemical and histopathologic features caused by acute intoxication with uranium.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.