Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis

International Journal of Molecular Sciences

Onju Ham²  Chang Youn Lee³  Ran Kim⁶  Jihyun Lee⁶  Sekyung Oh⁷  Min Young Lee⁵  Jongmin Kim⁴  Ki-Chul Hwang²  Lee-So Maeng¹  Woochul Chang⁶ 

[1] Institute of Catholic Integrative Medicine, Incheon St. Mary’s Hospital, the Catholic University of Korea, College of Medicine, Incheon 403-720, Korea;Catholic Kwandong University International St. Mary’s Hospital, Incheon 404-834, Korea; E-Mails:;Department of Integrated Omics for Biomedical Sciences, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759, Korea; E-Mail:;Department of Life Systems, Sookmyung Women’s University, Seoul 140-742, Korea; E-Mail:;Department of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 702-701, Korea; E-Mail:;Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Korea; E-Mails:;Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; E-Mail:

关键词: osteoarthritis;    mesenchymal stem cells;    microRNA;    small molecule;    differentiation;   

DOI  :  10.3390/ijms160714961

来源: mdpi

【 摘 要 】

Osteoarthritis (OA) is a chronic, progressive, and irreversible degenerative joint disease. Conventional OA treatments often result in complications such as pain and limited activity. However, transplantation of mesenchymal stem cells (MSCs) has several beneficial effects such as paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. In addition, MSCs can be differentiated into several cell types, including chondrocytes, osteocytes, endothelia, and adipocytes. Thus, transplantation of MSCs is a suggested therapeutic tool for treatment of OA. However, transplanted naïve MSCs can cause problems such as heterogeneous populations including differentiated MSCs and undifferentiated cells. To overcome this problem, new strategies for inducing differentiation of MSCs are needed. One possibility is the application of microRNA (miRNA) and small molecules, which regulate multiple molecular pathways and cellular processes such as differentiation. Here, we provide insight into possible strategies for cartilage regeneration by transplantation of differentiated MSCs to treat OA patients.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.