Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases

Journal of Clinical Medicine

Yves-Marie Pers¹ 

[1]Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital, 371, Avenue du Doyen Gaston Giraud, Montpellier 34295, France

[2] E-Mail

关键词: mesenchymal stem cells;    rheumatic diseases;    osteoarthritis;    rheumatoid arthritis;    autoimmune diseases;    immune tolerance;   

DOI  :  10.3390/jcm2040201

来源: mdpi

【 摘 要 】

Multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are adult stem cells exhibiting functional properties that have opened the way for cell-based clinical therapies. MSCs have been reported to exhibit immunosuppressive as well as healing properties, improving angiogenesis and preventing apoptosis or fibrosis through the secretion of paracrine mediators. This review summarizes recent progress on the clinical application of stem cells therapy in some inflammatory and degenerative rheumatic diseases. To date, most of the available data have been obtained in preclinical models and clinical efficacy needs to be evaluated through controlled randomized double-blind trials.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.