Purinergic System Signaling in Metainflammation-Associated Osteoarthritis

Frontiers in Medicine

article

Paula Gratal¹  Ana Lamuedra¹  Gabriel Herrero-Beaumont¹  Aránzazu Mediero¹ 

[1] Bone and Joint Research Unit

关键词: purinergic system;    A2AR;    P2X7 receptor;    osteoarthritis;    metainflammation;    mitochondrial metabolism;    Inflammasome;    rheumatic diseases;   

DOI  :  10.3389/fmed.2020.00506

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade inflammation caused by the components involved in metabolic syndrome (MetS), including central obesity and impaired glucose tolerance. This phenomenon is mainly due to excess nutrients and energy, and it contributes to the pathogenesis of osteoarthritis (OA). OA is characterized by the progressive degeneration of articular cartilage, which suffers erosion and progressively becomes thinner. Purinergic signaling is involved in several physiological and pathological processes, such as cell proliferation in development and tissue regeneration, neurotransmission and inflammation. Adenosine and ATP receptors, and other members of the signaling pathway, such as AMP-activated protein kinase (AMPK), are involved in obesity, type 2 diabetes (T2D) and OA progression. In this review, we focus on purinergic regulation in osteoarthritic cartilage and how different components of MetS, such as obesity and T2D, modulate the purinergic system in OA. In that regard, we describe the critical role in this disease of receptors, such as adenosine A2A receptor (A2AR) and ATP P2X7 receptor. Finally, we also assess how nucleotides regulate the inflammasome in OA.

【 授权许可】

CC BY