RNF20-SNF2H Pathway of Chromatin Relaxation in DNA Double-Strand Break Repair

Genes

Akihiro Kato¹  Kenshi Komatsu² 

[1] Division of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Yoshida-konoecho, Sakyo-ku, Kyoto 606-8501, Japan; E-Mail

关键词: DNA double-strand break repair;    ubiquitylation of histone H2B;    RNF20;    chromatin relaxation;    SNF2H;    KAP-1;    CHD3.1;   

DOI  :  10.3390/genes6030592

来源: mdpi

【 摘 要 】

Rapid progress in the study on the association of histone modifications with chromatin remodeling factors has broadened our understanding of chromatin dynamics in DNA transactions. In DNA double-strand break (DSB) repair, the well-known mark of histones is the phosphorylation of the H2A variant, H2AX, which has been used as a surrogate marker of DSBs. The ubiquitylation of histone H2B by RNF20 E3 ligase was recently found to be a DNA damage-induced histone modification. This modification is required for DSB repair and regulated by a distinctive pathway from that of histone H2AX phosphorylation. Moreover, the connection between H2B ubiquitylation and the chromatin remodeling activity of SNF2H has been elucidated. In this review, we summarize the current knowledge of RNF20-mediated processes and the molecular link to H2AX-mediated processes during DSB repair.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.