In Vitro Studies of Chromone-Tetrazoles against Pathogenic Protozoa, Bacteria, and Fungi

Molecules

Pedro A. Cano¹  Alejandro Islas-Jผome¹  Ángeles Rangel-Serrano²  Fernando Anaya-Velázquez²  Felipe Padilla-Vaca²  El໚s Trujillo-Esquivel²  Patricia Ponce-Noyola²  Antonio Martínez-Richa¹  Rocío Gámez-Montaño¹ 

[1] Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico; E-Mails:;Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico; E-Mails:

关键词: chromone-tetrazoles;    Ugi-azide reaction;    antimicrobial activity;    pathogenic protozoa;    pathogenic bacteria;    pathogenic fungi;    tropical diseases;   

DOI  :  10.3390/molecules200712436

来源: mdpi

【 摘 要 】

In vitro studies to fourteen previously synthesized chromone-tetrazoles and four novel fluorine-containing analogs were conducted against pathogenic protozoan (Entamoeba histolytica), pathogenic bacteria (Pseudomonas aeruginosa, and Staphylococcus aureus), and human fungal pathogens (Sporothrix schenckii, Candida albicans, and Candida tropicalis), which have become in a serious health problem, mainly in tropical countries.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.