New Eco-Friendly 1-Alkyl-3-(4-phenoxybutyl) Imidazolium-Based Ionic Liquids Derivatives: A Green Ultrasound-Assisted Synthesis, Characterization, Antibacterial Activity and POM Analyses

Molecules

Mouslim Messali³  Mohamed R. Aouad³  Wael S. El-Sayed¹  Adeeb Al-Sheikh Ali³  Taibi Ben Hadda² 

[1]Microbiology department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt

[2]Laboratoire de Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier, Oujda-60000, Morocco

[3]Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia

关键词: green procedure;    ultrasound irradiation;    ionic liquids;    antimicrobial activity;    Petra/Osiris/Molinspiration (POM) analyses;   

DOI  :  10.3390/molecules190811741

来源: mdpi

【 摘 要 】

In view of the emerging importance of the ILs as “green” materials with wide applications and our general interests in green processes, a series of a twenty five new 1-alkyl-3-(4-phenoxybutyl) imidazolium-based ionic liquids (ILs) derivatives is synthesized using a facile and green ultrasound-assisted procedure. Their structures were characterized by FT-IR, ¹H-NMR, ¹³C-NMR, ¹¹B, ¹⁹F, ³¹P, and mass spectrometry. Antimicrobial screens of some selected ILs were conducted against a panel of Gram-positive and Gram-negative bacteria. The antimicrobial activity of each compound was measured by determination of the minimal inhibitory concentration (MIC) yielding very interesting and promising results. Their antibacterial activities are reported, and, on the basis of the experimental and virtual POM screening data available, attempt is also made to elucidate the structure activity relationship.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.