“Greener” chemical syntheses using mechanochemical mixing or microwave and ultrasound irradiation

Green Chemistry Letters and Reviews

Rajender S. Varma¹ 

关键词: microwave irradiation;    mechanochemical mixing;    ultrasound irradiation;    Green chemical synthesis;    ionic liquids;    heterocycles;    nano-materials;    solid-supported reactions;    aqueous media;   

DOI  :  10.1080/17518250701756991

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

Various emerging “greener” strategic pathways, researched primarily in the author's own laboratory, are summarized. They include solvent-free mechanochemical methods that involve the use of hypervalent iodine reagents at room temperature for the synthesis of heterocyclic entities, and useful conversion of ketones into β-keto sulfones and their α-tosyloxy derivatives in high yields. A solvent-free approach that involves microwave (MW) exposure of neat reactants (undiluted) catalyzed by the surfaces of less-expensive and recyclable mineral supports, such as alumina, silica, clay, or “doped” surfaces, is described; it is applicable to a wide range of cleavage, condensation, cyclization, rearrangement, oxidation, and reduction reactions, including rapid one-pot assembly of heterocyclic compounds from in situ generated reactive intermediates. The strategy is adaptable to multi-component reactions, e.g. Ugi and Biginelli reactions, for rapid assembly of a library of compounds. Synthesis of a wide varie...

【 授权许可】

Unknown