Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes

Genes

Zhi-Peng Li²  Mei Zhang³  Jie Gao¹  Guo-Yan Zhou¹  Shuang-Qing Li²  Zhen-Mei An¹ 

[1] Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China; E-Mails:;Golden Card Hospital, West China Hospital, Sichuan University, Chengdu 610041, China; E-Mail:;Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China; E-Mail:

关键词: ADIPOQ;    type 2 diabetes;    genetic polymorphism;    case-control study;   

DOI  :  10.3390/genes6030512

来源: mdpi

【 摘 要 】

Objective: The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods: We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods. Results: We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44–2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54–0.81; p < 0.001). Conclusion: The ADIPOQ genetic polymorphisms were associated with type 2 diabetes in a Chinese population.

【 授权许可】

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