Relation between ADIPOQ gene polymorphisms and type 2 diabetes in a Chinese population

International Journal of Clinical and Experimental Medicine

Yun Xie¹  Wei-Lin Wang¹  Jin Li¹  Hong Zhu¹ 

关键词: ADIPOQ;    diabetes;    genetic polymorphism;    case-control study;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Objective: We aimed to investigate the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods: The present study included 510 subjects with normal glucose tolerant (NGT) and 510 patients with type 2 diabetic. Five SNPs (rs2241767, rs3821799, rs182052, rs1501299 and rs7627128) were genotyped by TaqMan methods. Results: Of these 5 SNPs, three SNPs (rs1501299, rs182052, and rs7627128) were found to be significantly associated with T2DM. The haplotypes AAT (Construction of rs1501299, rs182052, and rs7627128) was frequent in T2DM patients (OR=2.051, 95% CI: 1.439~2.923, P<0.001), but GAT (Construction of rs1501299, rs182052, and rs7627128) was frequent in the control group (OR=0.65, 95% CI: 0.540~0.805, P<0.001). Conclusion: The ADIPOQ gene variants and haplotype were associated with the risk for development of type 2 diabetes.

【 授权许可】

Unknown