C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer

Breast Cancer Research

Jiří Vácha²  Lydie Izakovičová-Hollá²  Jan Žaloudík³  Michal Jurajda²  Petr Beneš¹ 

[1] Department of Molecular Biology and Genetics, Faculty of Science, Masaryk University, Brno, Czech Republic;Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic;Masaryk Memorial Cancer Institute, Brno, Czech Republic

关键词: low-density lipoprotein receptor-related protein 1;    genetic polymorphism;    case-control study;    breast cancer;   

Others  :  1118805
DOI  :  10.1186/bcr591

 received in 2003-01-21, accepted in 2003-02-28,  发布年份 2003

【 摘 要 】

Background

Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression.

Methods

We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease.

Results

An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P = 0.01963). A significant excess of genotypes with the T allele (homozygotes plus heterozygotes) was also observed (odds ratio 1.743, 95% confidence interval 1.112–2.732).

Conclusion

The T allele of the C766T polymorphism in the LRP1 gene is associated with an increased risk of breast cancer development in women of Caucasian origin.

【 授权许可】

   
2003 Beneš et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

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