Immune Modulation by Vitamin D and Its Relevance to Food Allergy

Nutrients

Noor H. A. Suaini²  Yuxia Zhang¹  Peter J. Vuillermin²  Katrina J. Allen² 

[1] The Walter and Eliza Hall Institute of Medical Research, Parkville VIC 3052, Australia; E-Mails:;Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, VIC 3052, Australia; E-Mails:

关键词: vitamin D;    innate immunity;    adaptive immunity;    food allergy;    1;    25(OH)₂D₃;    T cells;    inflammation;    metabolism;    deficiency;   

DOI  :  10.3390/nu7085271

来源: mdpi

【 摘 要 】

Apart from its classical function in bone and calcium metabolism, vitamin D is also involved in immune regulation and has been linked to various cancers, immune disorders and allergic diseases. Within the innate and adaptive immune systems, the vitamin D receptor and enzymes in monocytes, dendritic cells, epithelial cells, T lymphocytes and B lymphocytes mediate the immune modulatory actions of vitamin D. Vitamin D insufficiency/deficiency early in life has been identified as one of the risk factors for food allergy. Several studies have observed an association between increasing latitude and food allergy prevalence, plausibly linked to lower ultraviolet radiation (UVR) exposure and vitamin D synthesis in the skin. Along with mounting epidemiological evidence of a link between vitamin D status and food allergy, mice and human studies have shed light on the modulatory properties of vitamin D on the innate and adaptive immune systems. This review will summarize the literature on the metabolism and immune modulatory properties of vitamin D, with particular reference to food allergy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.