Vitamin D and Immune Function

卷:5

Prietl, Barbara ; Treiber, Gerlies ; Pieber, Thomas R. ; Amrein, Karin

Med Univ Graz

关键词: vitamin D;    autoimmunity;    immune cells;    adaptive immunity;    innate immunity;    cholecalciferol;    calcitriol;    25(OH)D;   

DOI  :  10.3390/nu5072502

学科分类：食品科学和技术

【 摘 要 】

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.