Nutrients | |
Proanthocyanidins Prevent High Glucose-Induced Eye Malformation by Restoring |
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Rui-Rong Tan2  Shi-Jie Zhang2  Yi-Fang Li2  Bun Tsoi2  Wen-Shan Huang2  Nan Yao3  Mo Hong2  Yu-Jia Zhai2  Zhong-Fu Mao2  Lu-Ping Tang2  Hiroshi Kurihara2  Qi Wang1  | |
[1] Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;Anti-stress and Health Research Center, Pharmacy College, Jinan University, Guangzhou 510632, China; E-Mails:;Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Technology, Guangzhou 510095, China; E-Mail: | |
关键词:
proanthocyanidins;
hyperglycemia;
eye malformation;
oxidative stress;
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DOI : 10.3390/nu7085299 | |
来源: mdpi | |
【 摘 要 】
Gestational diabetes mellitus (GDM) is one of the leading causes of offspring malformations, in which eye malformation is an important disease. It has raised demand for therapy to improve fetal outcomes. In this study, we used chick embryo to establish a GDM model to study the protective effects of proanthocyanidins on eye development. Chick embryos were exposed to high glucose (0.2 mmol/egg) on embryo development day (EDD) 1. Proanthocyanidins (1 and 10 nmol/egg) were injected into the air sac on EDD 0. Results showed that both dosages of proanthocyanidins could prevent the eye malformation and rescue the high glucose-induced oxidative stress significantly, which the similar effects were showed in edaravone. However, proanthocyanidins could not decrease the glucose concentration of embryo eye. Moreover, the key genes regulating eye development,
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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