Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in Patients Suffering from Metabolic Syndrome with Hyperglycemia Are Associated to Dietary TAC and Fruit Consumption

International Journal of Molecular Sciences

Rocio de la Iglesia¹  Patricia Lopez-Legarrea¹  Paloma Celada²  Francisco J. Sánchez-Muniz²  J. Alfredo Martinez¹ 

[1] Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona 31008, Spain; E-Mails:;Department of Nutrition and Bromatology, The Complutense University of Madrid, Madrid 28040, Spain; E-Mails:

关键词: metabolic syndrome;    hyperglycemia;    oxidative stress;    TAC;    fruit;   

DOI  :  10.3390/ijms14046903

来源: mdpi

【 摘 要 】

Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS), whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (−30% Energy): the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates), which was characterized by an increase of the meal frequency (seven-times/day), low glycemic load, high antioxidant capacity (TAC) and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra) diet specifically reduced the android fat mass and demonstrated more effectiveness on improving general oxidative stress through a greater decrease of oxidized LDL (oxLDL) values and protection against arylesterase depletion. Interestingly, oxLDL values were associated with dietary TAC and fruit consumption and with changes on body mass index (BMI), waist circumference, fat mass and triacilglyceride (TG) levels. In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland