Perfluoroalkyl-Functionalized Hyperbranched Polyglycerol as Pore Forming Agents and Supramolecular Hosts in Polymer Microspheres

International Journal of Molecular Sciences

Olaf Wagner²  Maximilian Zieringer¹  Wynter J. Duncanson¹  David A. Weitz¹  Rainer Haag² 

[1] School of Engineering and Applied Sciences, Harvard University, 29 Oxford St., Cambridge, MA 02138, USA; E-Mails:;Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, Berlin 14195, Germany; E-Mail:

关键词: polyglycerol;    non-covalent;    fluorous;    supramolecular;    microbubbles;    microfluidics;    porous;    template;    functional;    host-guest system;   

DOI  :  10.3390/ijms160920183

来源: mdpi

【 摘 要 】

Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12% (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.