Perfluoroalkyl-Functionalized Hyperbranched Polyglycerolas Pore Forming Agents and Supramolecular Hosts inPolymer Microspheres

International Journal of Molecular Sciences

Olaf Wagner¹  Rainer Haag¹  Maximilian Zieringer²  David A. Weitz²  Wynter J. Duncanson² 

[1] Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, Berlin 14195, Germany;School of Engineering and Applied Sciences, Harvard University, 29 Oxford St., Cambridge,MA 02138, USA;

关键词: polyglycerol;    non-covalent;    fluorous;    supramolecular;    microbubbles;    microfluidics;    porous;    template;    functional;    host-guest system;   

DOI  :  10.3390/ijms160920183

来源: DOAJ

【 摘 要 】

Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres.In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12% (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction.

【 授权许可】

Unknown