Effects of Prepartum Dietary Energy Level and Nicotinic Acid Supplementation on Immunological, Hematological and Biochemical Parameters of Periparturient Dairy Cows Differing in Parity

Animals

Reka Tienken¹  Susanne Kersten¹  Jana Frahm¹  Liane Hüther¹  Ulrich Meyer¹  Korinna Huber³  Jürgen Rehage²  Sven Dänicke¹ 

[1] Institute of Animal Nutrition, Friedrich-Loeffler-Insitute (FLI), Federal Research Institute for Animal Health, Bundesallee 50, 38116 Brunswick, Germany; E-Mails:;Clinic for Cattle, University of Veterinary Medicine Hanover, Bischofsholer Damm 15, 30173 Hanover, Germany; E-Mail:;Department of Physiology, University of Veterinary Medicine Hanover, Bischofsholer Damm 15, 30173 Hanover, Germany

关键词: periparturient;    niacin;    dairy cow;    immune system;    PBMC;    CD4;    CD8;   

DOI  :  10.3390/ani5030391

来源: mdpi

【 摘 要 】

Several biological changes occur during the transition from late pregnancy to early lactation which is associated with a high susceptibility of health disorders. Nicotinic acid, as feed additive, is suggested to balance catabolic metabolism of periparturient dairy cows by attenuating lipolysis and impact production performance. This study provides information of the biological changes occurring around parturition with special emphasis on differences between primiparous and multiparous cows. Present results showed that energy-dense feeding prepartum did not result in metabolic imbalances postpartum in dairy cows which were similar in body condition score. Nicotinic acid supplementation did not reveal any effect.

The periparturient period is critical according to health, productivity and profitability. As this period is fundamental for the success of the lactation period, the interest in improving periparturient health by dietary supplements increased in recent years. The present study investigated the effects of feeding nicotinic acid (NA) combined with varying dietary energy densities on immunological, hematological and biochemical parameters of periparturient cows differing in parity. Thirty-six multiparous and 20 primiparous dairy cows were enrolled in the study 42 days before expected parturition date until 100 days postpartum with the half of the cows being supplemented with 24 g of NA/d. After parturition a diet with 30% concentrate was fed to all cows which was followed by different concentrate escalation strategies. Dietary NA supplementation was ceased on day 24 postpartum. Dietary NA increased (P = 0.010) serum nicotinamide concentrations (mean of 3.35 ± 1.65 µg/mL), whereas NA could not be detected. Present data emphasize that periparturient cows are faced with major physiological challenges and that both parity-groups have different prerequisites to adapt to those changes irrespective of NA supplementation. The overfeeding of energy to cows which were similar in body condition score had only minor effects on periparturient immune system function and the metabolism of those cows.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.