Changes in Peripheral Blood Mononuclear Cells after Calving in Lactating Cows with Serious Decrease of Body Weight before and after Calving

Journal of Veterinary Medical Science

Hitomi KASE³  Seiichi KAWAMURA³  Takaaki ANDO³  Hiromichi OHTSUKA³  Masayuki KOHIRUIMAKI³  Daisaku WATANABE³  Tomohito HAYASHI¹  Machiko MASUI² 

[1] Research Institute for Biological Sciences, Tokyo University of Science;Kohiruimaki Animal Medical Service;School of Veterinary Medicine, Kitasato University

关键词: body weight;    dairy cow;    immune function;    periparturient;   

DOI  :  10.1292/jvms.70.153

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(27)Cited-By(2)The aim of this study was to clarify the hormonal and immunological changes in periparturient dairy cows with excessive weight loss following calving. We analyzed leukocyte populations and the peripheral blood mononuclear cell (PBMC) mRNA of IFN-γ, IL-4, growth hormone (GH)-receptor (R) and insulin -R and measured the GH and insulin concentrations. Ten dairy cows fed in one herd were used in this study and were divided into two groups. Five cows that experienced loss of body weight following calving of over 10% comprised the Weight Loss Group, and the remaining five cows, which experienced loss of body weight of 5% or less following calving, served as the Control Group. The Weight Loss Group had high serum cholesterol and low blood urea nitrogen levels compared with the Control Group throughout the period of observation. In regard to the leukocyte populations, there were significantly fewer CD4+CD45R-T cells in the Weight Loss Group 1 to 2 months after calving compared with the Control Group. The percentage of IFN-γ/IL-4 among PBMCs in the Weight Loss Group tended to be lower than in the Control Group throughout the observation period. In the Weight Loss Group, the levels of GH-R during month 2 were lower than in the Control Group. We concluded that excessive loss of body weight in dairy cows following calving is associated with depressed cellular immune function.

【 授权许可】

Unknown