Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Diagnostics

Kamilla Westarp Zornhagen¹  Malene M. Clausen²  Anders E. Hansen⁴  Ian Law²  Fintan J. McEvoy¹  Svend A. Engelholm³  Andreas Kjær²  Annemarie T. Kristensen¹ 

[1] Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, Denmark; E-Mails:;Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark; E-Mails:;Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2200 Copenhagen N, Denmark; E-Mail:;Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345E, DK-2800 Kgs. Lyngby, Denmark; E-Mail:

关键词: ¹⁸F-FDG;    ¹⁸F-FLT;    ⁶⁴Cu-ATSM;    positron emission tomography;    PET/CT;    individualized response monitoring;    canine fibrosarcoma;   

DOI  :  10.3390/diagnostics5030372

来源: mdpi

【 摘 要 】

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using ¹⁸F-FDG, ⁶⁴Cu-ATSM, and ¹⁸F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in ¹⁸F-FDG and ¹⁸F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.