Integrating Microtissues in Nanofiber Scaffolds for Regenerative Nanomedicine

Materials

Laetitia Keller¹  Quentin Wagner¹  Damien Offner¹  Sandy Eap¹  Anne-Marie Musset⁴  Manuel Arruebo³  Jens M. Kelm²  Pascale Schwinté¹  Nadia Benkirane-Jessel¹ 

[1] INSERM (French National Institute of Health and Medical Research), “Osteoarticular and Dental Regenerative Nanomedicine” laboratory, UMR 1109, Faculté de Médecine, Strasbourg Cedex F-67085, France;InSphero AG, Wagistrasse 27, Schlieren 8952, Switzerland;Department of Chemical Engineering and Aragon Nanoscience Institute, University of Zaragoza, C/Mariano Esquillor, s/n, Zaragoza 50018, Spain;;Université de Strasbourg, Faculté de Chirurgie Dentaire, 1 place de l’Hôpital, Strasbourg F-67000, France

关键词: nanofibrous implant;    microtissues;    regenerative nanomedicine;    bone regeneration;   

DOI  :  10.3390/ma8105342

来源: mdpi

【 摘 要 】

A new generation of biomaterials focus on smart materials incorporating cells. Here, we describe a novel generation of synthetic nanofibrous implant functionalized with living microtissues for regenerative nanomedicine. The strategy designed here enhances the effectiveness of therapeutic implants compared to current approaches used in the clinic today based on single cells added to the implant.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.