Adjunctive Application of Antimicrobial Photodynamic Therapy in Nonsurgical Periodontal Treatment: A Review of Literature

International Journal of Molecular Sciences

Takeshi Kikuchi¹  Makio Mogi²  Iichiro Okabe¹  Kosuke Okada¹  Hisashi Goto¹  Yasuyuki Sasaki¹  Takeki Fujimura¹  Mitsuo Fukuda¹  Akio Mitani¹ 

[1] Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464-8651, Japan; E-Mails:;Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi 464-8650, Japan; E-Mail:

关键词: photodynamic therapy;    antimicrobial photodynamic therapy;    periodontal treatment;    periodontal disease;    periodontal pathogenic bacteria;    low-power laser;    photosensitizer;   

DOI  :  10.3390/ijms161024111

来源: mdpi

【 摘 要 】

Periodontal disease is caused by dental plaque biofilms, and the removal of these biofilms from the root surface of teeth plays a central part in its treatment. The conventional treatment for periodontal disease fails to remove periodontal infection in a subset of cases, such as those with complicated root morphology. Adjunctive antimicrobial photodynamic therapy (aPDT) has been proposed as an additional treatment for this infectious disease. Many periodontal pathogenic bacteria are susceptible to low-power lasers in the presence of dyes, such as methylene blue, toluidine blue O, malachite green, and indocyanine green. aPDT uses these light-activated photosensitizer that is incorporated selectively by bacteria and absorbs a low-power laser/light with an appropriate wavelength to induce singlet oxygen and free radicals, which are toxic to bacteria. While this technique has been evaluated by many clinical studies, some systematic reviews and meta-analyses have reported controversial results about the benefits of aPDT for periodontal treatment. In the light of these previous reports, the aim of this review is to provide comprehensive information about aPDT and help extend knowledge of advanced laser therapy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.