Photodynamic Therapy Using 5-Aminolevulinic Acid (Ala) for the Treatment of Chronic Periodontitis: A Prospective Case Series

Applied Sciences

Giulia Moreo¹  Annalisa Palmieri²  Dorina Lauritano³  Francesco Carinci³  Fedora Della Vella⁴  Massimo Petruzzi⁴  Daniele Botticelli⁵ 

[1] Department of Biomedical, Surgical and Dental Sciences University of Milan, 20122 Milan, Italy;Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40126 Bologna, Italy;Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy;Interdisciplinary Department of Medicine, University of Bari, 70121 Bari, Italy;Private practice, 47921 Rimini, Italy;

关键词: periodontal disease;    chronic periodontitis;    moderate and severe periodontitis;    adjuvant periodontal treatment;    photodynamic therapy;    5-aminolevulinic acid;   

DOI  :  10.3390/app12063102

来源: DOAJ

【 摘 要 】

Aim: The objective of this study was to compare the efficacy of supportive periodontal therapy (i.e., scaling and root planning, SRP) alone versus ALADENT medical device used in association with SRP in the treatment of chronic periodontitis in adult patients. Materials and Methods: A total of 20 patients with a diagnosis of chronic periodontitis (40 localized chronic periodontitis sites) aged between 35 and 55 were selected. None of these patients previously received any surgical or non-surgical periodontal therapy, and they presented radiographic evidence of moderate bone loss. Two non-adjacent sites in different quadrants were identified and observed in each patient, analyzing treatment effectiveness (split-mouth design). Clinical pocket depth, clinical attachment loss, and bleeding on probing were evaluated at time 0 and after 6 months, while microbial analysis (MA) was conducted at baseline and after 15 days. Significant differences were calculated using SPSS program and paired simple statistic t-test. Results: Total bacteria loadings had a statistically significant reduction before and after treatment with SRP (left site) (total average decrease of 27%). The sites treated with SRP plus ALADENT (right) showed a significantly reduced total bacterial loading compared to the untreated sites (right) (total average decrease of 75%). Mean values of CAL/PD and percentages data of BOP, recorded after SRP + ALADENT therapy, showed a higher reduction (CAL = 2.42, PD = 2.87 mm, 90% of sites with no bleeding) than those obtained after SRP treatment (CAL = 4.08 mm, PD = 4.73 mm, 70% of sites with no bleeding). Conclusion: The treatment of moderate and severe chronic periodontitis should include, beside SRP, the use of ALADENT medical device, which has been proved to be a useful adjuvant therapy.

【 授权许可】

Unknown