One-Year Clinical, Microbiological and Immunological Results of Local Doxycycline or Antimicrobial Photodynamic Therapy for Recurrent/Persisting Periodontal Pockets: A Randomized Clinical Trial

Antibiotics

Nicole Birgit Arweiler¹  Raluca Cosgarea²  Pia Merete Jervøe-Storm²  Søren Jepsen²  Christoph A. Ramseier³  Sigrun Eick³  Anton Sculean³  Ionela Batori-Andronescu⁴  Torsten Conrad⁵  Ralf Rößler⁵ 

[1] Clinic for Periodontology and Peri-Implant Diseases, Philipps University Marburg, 35033 Marburg, Germany;Department for Periodontology, Operative and Preventive Dentistry, University of Bonn, 53111 Bonn, Germany;Department of Periodontology, School of Dentistry, University of Bern, 3010 Bern, Switzerland;Department, Periodontal Private Practice Cosmedica, 400185 Cluj-Napoca, Romania;University for Digital Technologies in Medicine and Dentistry, 9516 Wiltz, Luxembourg;

关键词: supportive periodontal therapy;    photodynamic therapy;    local drug delivery;    periodontal treatment;    persistent periodontal pockets;   

DOI  :  10.3390/antibiotics11060738

来源: DOAJ

【 摘 要 】

We evaluated, in this study, the clinical, microbiological and immunological effects of local drug delivery (LDD) or photodynamic therapy (PDT), adjunctive to subgingival instrumentation (SI) in persistent or recurrent periodontal pockets in patients enrolled in supportive periodontal therapy (SPT) after one year. A total of 105 patients enrolled in SPT with persistent/recurrent pockets were randomly treated with SI +PDT or SI + LDD or SI (control). The number of treated sites with bleeding on probing (n BOP+), probing pocket depths (PPD), clinical attachment level (CAL), full-mouth plaque and bleeding scores (gingival bleeding index, %bleeding on probing-BOP) was evaluated at baseline and after 12 months. Additionally, eight periodontopathogens and the immunomarkers IL-1β (interleukin)and MMP-8 (matrix metalloprotease) were quantitatively determined using real-time PCR and ELISA, respectively. All three treatments resulted in statistically significant clinical improvements (p < 0.05) without statistically significant intergroup differences (p > 0.05), which were maintained up to 12 months. The presence of BOP negatively affected the PPD and CAL. Moreover, statistically significantly fewer bleeding sites at 12 months were observed in the test groups (p = 0.049). Several periodontopathogens were reduced after 12 months. In conclusion, the present data indicate that in periodontal patients enrolled in SPT, treatment of persistent/recurrent pockets with SI alone or combined with either PDT or LDD may lead to comparable clinical, microbiological and immunological improvements, which are maintained up to 12 months. Secondly, the presence of BOP directly impacts the PPD and CAL.

【 授权许可】

Unknown