Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Polymers

Jin-Hyung Shim¹  Joo-Yun Won²  Su-Jin Sung³  Dong-Hyuk Lim¹  Won-Soo Yun¹  Young-Chan Jeon³  Jung-Bo Huh³ 

[1] Department of Mechanical Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do, 15073, Korea;Research Institute, T&R Biofab Co. Ltd., 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do, 15073, Korea;Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, YangSan, Gyeongnam 676-870, Korea;

关键词: PCL/PLGA/β-TCP;    3D printing;    titanium membrane;    guided bone regeneration;    osseointegration;    beagle dog;   

DOI  :  10.3390/polym7101500

来源: mdpi

【 摘 要 】

This study was conducted to evaluate the effects of a 3D-printed resorbable polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PCL/PLGA/β-TCP) membrane on bone regeneration and osseointegration in areas surrounding implants and to compare results with those of a non-resorbable titanium mesh membrane. After preparation of PCL/PLGA/β-TCP membranes using extrusion-based 3D printing technology; mechanical tensile testing and in vitro cell proliferation testing were performed. Implant surgery and guided bone regeneration were performed randomly in three groups (a no membrane group, a titanium membrane group, and a PCL/PLGA/β-TCP membrane group (n = 8 per group)). Histological and histometric analyses were conducted to evaluate effects on bone regeneration and osseointegration. Using the results of mechanical testing; a PCL/PLGA/β-TCP ratio of 2:6:2 was selected. The new bone areas (%) in buccal defects around implants were highest in the PCL/PLGA/β-TCP group and significantly higher than in the control group (p < 0.05). Bone-to-implant contact ratios (%) were also significantly higher in the PCL/PLGA/β-TCP and titanium groups than in the control group (p < 0.05). When the guided bone regeneration procedure was performed using the PCL/PLGA/β-TCP membrane; new bone formation around the implant and osseointegration were not inferior to those of the non-resorbable pre-formed titanium mesh membrane.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.