Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism

International Journal of Molecular Sciences

Anna Falkowska²  Izabela Gutowska³  Marta Goschorska²  Przemysław Nowacki¹  Dariusz Chlubek²  Irena Baranowska-Bosiacka² 

[1] Department of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-225 Szczecin, Poland;Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland;Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460 Szczecin, Poland;

关键词: brain energy metabolism;    astrocytes;    brain;    glucose;    glycogen;    neurons;   

DOI  :  10.3390/ijms161125939

来源: mdpi

【 摘 要 】

Glycogen metabolism has important implications for the functioning of the brain, especially the cooperation between astrocytes and neurons. According to various research data, in a glycogen deficiency (for example during hypoglycemia) glycogen supplies are used to generate lactate, which is then transported to neighboring neurons. Likewise, during periods of intense activity of the nervous system, when the energy demand exceeds supply, astrocyte glycogen is immediately converted to lactate, some of which is transported to the neurons. Thus, glycogen from astrocytes functions as a kind of protection against hypoglycemia, ensuring preservation of neuronal function. The neuroprotective effect of lactate during hypoglycemia or cerebral ischemia has been reported in literature. This review goes on to emphasize that while neurons and astrocytes differ in metabolic profile, they interact to form a common metabolic cooperation.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.