期刊论文详细信息
Sensors
Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles
Congo Tak-Shing Ching3  Nguyen van Hieu1  Teng-Yun Cheng3  Lin-Shien Fu2  Tai-Ping Sun3  Ming-Yen Liu3  Su-Hua Huang4  Yan-Dong Yao5 
[1] Department of Physics and Electronic Engineering, University of Science (Vietnam National University of Hochiminh City), District 5, Hochiminh City 999100, Vietnam; E-Mail:;Department of Pediatrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan; E-Mail:;Department of Electrical Engineering, National Chi Nan University, Nantou 54561, Taiwan; E-Mails:;Department of Biotechnology, Asia University, Taichung 41354, Taiwan;Division of Science & Technology, Hong Kong Community College, Hong Kong, China; E-Mail:
关键词: liver cancer;    DCP;    immunosensor;    screening;    nanoparticle;   
DOI  :  10.3390/s151129408
来源: mdpi
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【 摘 要 】

Regular monitoring of blood α-fetoprotein (AFP) and/or carcino-embryonic antigen (CEA) levels is important for the routine screening of liver cancer. However, AFP and CEA have a much lower specificity than des-γ-carboxyprothrombin (DCP) to detect liver cancer. Therefore, the study reported here was designed, to develop a screen-printed DCP immunosensor incorporating zinc oxide nanoparticles, for accurate determination of DCP. The designed immunosensor shows low detection limits for the detection of DCP: 0.440 ng/mL (based on impedance measurement), 0.081 ng/mL (based on real part of impedance measurement) and 0.078 ng/mL (based on imaginary part of impedance measurement), within the range of 3.125 ng/mL to 2000 ng/mL. In addition, there was little interference to DCP determination by molecules such as Na+, K+, Ca2+, Cl, glucose, urea, and uric acid. It is therefore concluded that the DCP immunosensor developed and reported here is simple, inexpensive and effective, and shows promise in the rapid screening of early-stage liver cancer at home with a point-of-care approach.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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