Penetration enhancement across a model membrane by liposomally entrapped drugs using N,N′‐diacylcystine as a bilayer lipid

FEBS Letters

Kikkawa, Masayoshi²  Okabe, Hideaki¹  Kainose, Hisayasu¹  Kamagami, Saburo¹  Ishigami, Yutaka² 

[1] Lintec Corporation, Research Laboratory, Nishikieho, Warabi, Saitama, 335, Japan;National Chemical Laboratory for Industry, Tsukuba, Ibaraki 305, Japan

关键词: Liposomally entrapped drug;    Penetration enhancement;    N;    N′-Diacyl L-cystine;    Keratin membrane;    PBS;    phosphate-buffered saline;    PABA;    p-aminobenzoic acid;    C8-SS;    N;    N′-dioctanoyl L-cystine;    C12-SS;    N;    N′-dilauroyl L-cystine;    DCP;    dicetyl phosphate;   

DOI  :  10.1016/0014-5793(91)80376-E

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A liposomal system for percutaneous absorption and transdermal drug delivery was developed and evaluated using a model apparatus connecting two chambers by a membrane. When N,N′-long chain diacyl L-cystine was incorporated into the liposomal bilayer as well lecithin and cholesterol, liposomally entrapped calccin as the model drug transferred well across the keratin membrane functioning as the skin model.

【 授权许可】

Unknown