Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans

Toxins

Zhendong Yang¹  Kathy S. Xue²  Xiulan Sun¹  Lili Tang²  Jia-Sheng Wang² 

[1] Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science, Jiangnan University, Wuxi, Jiangsu 214122, China;Department of Environmental Health Science, University of Georgia, Athens, GA 30602, USA;

关键词: aflatoxin B₁;    Caenorhabditis elegans;    deoxynivalenol;    fumonisin B₁;    mycotoxins;    T-2 toxin;    zearalenone;   

DOI  :  10.3390/toxins7124876

来源: mdpi

【 摘 要 】

Aflatoxins B₁ (AFB₁), deoxynivalenol (DON), fumonisin B₁ (FB₁), T-2 toxin (T-2), and zearalenone (ZEA) are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC₅₀ at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB₁ toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB₁, FB₁, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.