Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens

Toxins

Gunther Antonissen³  Mathias Devreese³  Filip Van Immerseel¹  Siegrid De Baere³  Sabine Hessenberger²  An Martel¹  Siska Croubels³ 

[1]Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium

[2] E-Mails:

[3]Biomin Research Center, Technopark 1, Tulln 3430, Austria

[4] E-Mail:

[5]Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium

[6] E-Mails:

关键词: Fusarium toxins;    deoxynivalenol;    fumonisin B₁;    broiler chickens;    toxicokinetics;    oral bioavailability;   

DOI  :  10.3390/toxins7020560

来源: mdpi

【 摘 要 】

Both deoxynivalenol (DON) and fumonisin B₁ (FB₁) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecting the intestinal surface area and function of the tight junctions. This might influence the oral bioavailability of FB₁, and possibly lead to altered toxicity of this mycotoxin. A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5 mg FBs/kg BW after three-week exposure to either uncontaminated feed (group 1) or feed contaminated with 3.12 mg DON/kg feed (group 2). No significant differences in toxicokinetic parameters of FB₁ could be demonstrated between the groups. Also, no increased or decreased body exposure to FB₁ was observed, since the relative oral bioavailability of FB₁ after chronic DON exposure was 92.2%.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.