Upconverting NIR Photons for Bioimaging

Nanomaterials

Zhanjun Li²  Yuanwei Zhang²  Hieu La²  Richard Zhu²  Ghida El-Banna²  Yuzou Wei²  Gang Han¹ 

[1] Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA;

关键词: upconversion nanoparticles;    optical imaging;    optical therapy;   

DOI  :  10.3390/nano5042148

来源: mdpi

【 摘 要 】

Lanthanide-doped upconverting nanoparticles (UCNPs) possess unique anti-Stokes optical properties, in which low energy near-infrared (NIR) photons can be converted into high energy UV, visible, shorter NIR emission via multiphoton upconversion processes. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPs can be fabricated with narrow distribution and tunable multi-color optical properties. These unique attributes grant them unique NIR-driven imaging/drug delivery/therapeutic applications, especially in the cases of deep tissue environments. In this brief review, we introduce both the basic concepts of and recent progress with UCNPs in material engineering and theranostic applications in imaging, molecular delivery, and tumor therapeutics. The aim of this brief review is to address the most typical progress in basic mechanism, material design as bioimaging tools.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.