Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions

Molecules

El Sayed H. El Ashry¹  Yeldez El Kilany¹  Nariman M. Nahas²  Assem Barakat¹  Nadia Al-Qurashi²  Hazem A. Ghabbour³  Hoong-Kun Fun³ 

[1] Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426, Alexandria 21321, Egypt;Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia;Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia;

关键词: benzimidazole-thione;    thiazino[3;    2-a]benzimidazole;    X-ray;   

DOI  :  10.3390/molecules21010012

来源: mdpi

【 摘 要 】

Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, ¹H-NMR, ¹³C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P2₁/c, respectively.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.