Characteristics of Tau and Its Ligands in PET Imaging

Biomolecules

Ryuichi Harada¹  Nobuyuki Okamura¹  Shozo Furumoto⁴  Tetsuro Tago⁴  Kazuhiko Yanai²  Hiroyuki Arai⁵  Yukitsuka Kudo¹  Claude M. Wischik³ 

[1] Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;Department of Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;;Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JapanDivision of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, 6-3Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan;Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;

关键词: Alzheimer’s disease;    tau deposits;    positron emission tomography;    radiotracer;   

DOI  :  10.3390/biom6010007

来源: mdpi

【 摘 要 】

Tau deposition is one of the neuropathological hallmarks in Alzheimer’s disease as well as in other neurodegenerative disorders called tauopathies. Recent efforts to develop selective tau radiopharmaceuticals have allowed the visualization of tau deposits in vivo. In vivo tau imaging allows the assessment of the regional distribution of tau deposits in a single human subject over time for determining the pathophysiology of tau accumulation in aging and neurodegenerative conditions as well as for application in drug discovery of anti-dementia drugs as surrogate markers. However, tau deposits show complicated characteristics because of different isoform composition, histopathology, and ultrastructure in various neurodegenerative conditions. In addition, since tau radiopharmaceuticals possess different chemotype classes, they may show different binding characteristics with heterogeneous tau deposits. In this review, we describe the characteristics of tau deposits and their ligands that have β-sheet binding properties, and the status of tau imaging in clinical studies.

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.